Researchers Report on Recurrent Mutations in Down Syndrome-related Myeloid Condition, Blood Cancer

by GenomeWeb Daily News:
A single gene appears to be the main culprit in a myeloid proliferation complication called transient abnormal myelopoiesis, or TAM, that's sometimes seen in individuals with Down syndrome, according to a study online yesterday in Nature Genetics, which usedsequencing to characterize the alterations associated with TAM and a related blood cancer.

A team led by investigators at the University of Tokyo, Kyoto University, and Hirosaki University used genome sequencing, exome sequencing, and targeted genomic assessments to tally up genetic changes involved in the often-temporary myeloid condition most akin to acute megakaryoblastic leukemia.