Showing posts with label SAG. Show all posts
Showing posts with label SAG. Show all posts

Wednesday, September 18, 2013

Misleading claims of 'cure for Down's syndrome'

from Nursing Times:
The Mail Online suggests there could be a “cure” for Down syndrome, saying that scientists have “discovered a way to reverse the learning difficulties caused by the condition”.
It is not apparent from this headline that the research in question was carried out in mice, not people with Down syndrome. The mice had a genetic abnormality that mimics some of the characteristics of Down syndrome in humans. The study investigated the effects of a compound (called Sonic hedgehog pathway agonist, SAG) which the researchers thought might reduce some of the aspects of problems with the brain structure, learning and memory of mice.
When the mice were given SAG at birth, by adulthood they had more normal development in the part of the brain involved with balance and coordination than untreated mice. The treated mice also showed improvements in nerve signalling in a part of the brain involved with memory and spatial awareness. They also performed better on a test of learning and memory. However, SAG treated mice still showed differences in some nerve cell signalling and behavioural tasks compared to normal mice.
It is not possible to correct the underlying genetic abnormality that causes Down syndrome, so talk of a “cure” is misleading.